The sky is not blue. We are neither up nor down.
The sky appears blue when light of a certain wavelength hits the cones in our eyes, and we percieve it as blue, although I cannot be certain that your subjective perception of blue is the same as mine.
Science makes assumptions, but unlike religion, they are only tentative, provisional, and open to change based on further knowledge.
The "simplest" questions of science are not inexplicable, meaning we can never know. Only supernatural things are inexplicable. As yet we don't know wether something can be eventually known or not, but science has a good track record so far. I think everything is explicable.
e.g. if you break down all things in the universe to the smallest base unit that it is comprised of, can we answer the question "what is life?"
There are no base units. Life is not clearly separate from non-life, it's a continuum.
Science can answer the what and to a very limited extent it can answer the how (which of course builds with every advance we make) but it can never really answer the why.
It can, and has. For some things the question why doesn't apply. It is a particular human trait to apply motive to phenomenon, and probably has an evolutionary origin.
And seeing as we are dissatisfied with incomplete equations,
On the contrary, only the religious are dissatisfied with incomplete equations. scientists love a good puzzle.
we can never be satisfied with a world where the why is incomplete.
The concept of intellectual satisfaction is conditioned into people by religion. Satisfaction is death. The persuit of knowledge is infinite. We seek patterns, but everything we find out reveals more mystery.
Yes, we are more than the sum of our parts, but if we become aware of the parts, how much more wonderous is that sum!