"What is commonly called « lie detector » is actually a polygraph that
essentially measures four parameters : heart rate, blood pressure,
respiration, and sweating (see the image at the bottom). The variation of
these parameters may be associated with some emotions but the question is
highly controversial. To my opinion, what should be clear is that the
polygraph measures the parameters mentioned above but not in any way
whether a person is telling the truth or not. Moreover, the output from a
polygraph may fail to detect real emotions (ex. fear) behind lying.
Indeed, a 1983 report by the Office of Technology Assessment concluded
that polygraphs are not an effective scientific method to check for
security breaches. I also think that having “false positive” is very
dangerous: a person may tell the truth while being highly stressed by the
situation. According to Alan P. Zelicoff (physicist at the Center for
National Security and Arms Control at Sandia National Laboratories in
Albuquerque, New Mexico): there are “tremendous cynicism and doubt about
the utility of the test in both management and technical staff.”
To answer your question more precisely, there are no study that have used
PET or fMRI as a “lie detector”. On the other hand, some people think that
it would yield better results than the polygraph because there are growing
evidence that certain parts of the brain are involved with emotions
(discussed briefly in Holden, 2001). On the other hand, one must remember
that emotions does not necessarily mean truth or lie although it may be
indicative in some cases."
http://www.madsci.org/posts/archives/2001-07/994841079.Ns.r.html