According to my argument that in reality there is no UP, these fluctuations must not exist. If they exist I will have to give a good reason for why they are experimentally observable. Yikes!
Quantum tunnelling is an example, where you confine an electron to a magnetic trap, where the energy required to overcome the 'walls' of the trap is many many times larger than the thermal energy of the electron.
In principle you could then push the walls of the trap closer and closer and closer together, eventually confining the particle to a region of space so small that it can't move and then you have it's position and momentum, in violation of the UP. Except this isn't what occurs. As you become more certain of the electron's location QM says you're more and more uncertain of its momentum. Eventually the momentum is enough to overcome the walls of the trap and the particle tunnels out, becoming free.
This is what also governs nuclear decays. Alpha particles overcome the potential trapping them in the nucleus and they escape. This doesn't happen classically, if you have a ball sitting at the bottom of a hill and you wait and wait and wait, it's not going to suddenly run
up hill and down the other side, even if the other side of the hill is lower than where it currently sits. Quantum mechanics does allow it to happen, as overall the potential of the alpha particle is reduced, once it gets out of the clutches of the nucleus.
Beta decay is even more an example, as it's mediated by weak bosons. A neutron has a mass of about 1GeV. A W- has a mass of 90 GeV. Yet for a split second its possible for one of the quarks in the neutron to emit a W-, a particle
thousands of times its own mass (up and down quarks are only a few MeV in rest mass), which then decays into an electron and an neutrino. This is only possible quantum mechanically, you have an uncertainty relating time and energy (they are conjugate variables in the same way position and momentum are) so its possible for particles to suddenly have lots of energy, provided its only over short times but that's enough to mediate beta decay.
The vacuum fluctuations you mention are precisely that, the universe itself is uncertain of the amount of energy in a region of space and these fluctuations can be viewed as particles flittering in and out of existence. Over large time frames the fluctuations factor out to be undetectable but if you look at a small enough region of space very quickly you'll find a lot of high speed massive particles, as its the only way you can obey the UP. Without that ability to overcome barriers which would be classically insurmountable you'd not get nuclear decays and things like the stability of particles ties in very very closely to the conditions required for our kind of life to exist. If neutrons decayed to protons too quickly or too slowly nuclear physics and thus the dynamics of the Sun would be quite different.