James Hogan
Registered Member
This is part of the section from the Denis Noble paper about inheritance of acquired characteristics:
He seems to have come to the same conclusion as Eva Jablonka.
If you google search for Jablonkas paper:
Soft inheritance: challenging the modern synthesis
Abstract
JABLONKA, Eva and LAMB, Marion J.. Soft inheritance: challenging the modern synthesis. Genet. Mol. Biol. [online]. 2008, vol.31, n.2 [cited 2013-07-16], pp. 389-395.
As you can see more and more scientists are supporting an extended evolutionary synthesis which has "Lamarckian" components. As the other user pointed out this is not knew as Gould was arguing for something similar in the 1970s but this position has now become "mainstream" I. e. many scientists are now arguing for an extended synthesis.
But the evidence for the inheritance of acquired characteristics has now moved right into the
zoological domain. All the remaining examples I shall quote here are on multicellular organisms,
including mammals, and they refer to pioneering work done in the last 7 years.
Anway et al (Anway, Leathers et al. 2006; Anway, Memon et al. 2006) demonstrated that an
endocrine disruptor vinclozolin (an anti-androgenic compound), can induce transgenerational disease
states or abnormalities which are inherited for at least four generations in rats. The transmission is via
epigenetic modifications carried by the male germ line and may involve either marking of the genome
or transmission of RNAs. More recent work from the same laboratory has shown that the third
generation granulosa cells carry a transgenerational effect on the transcriptome and epigenome
through differential DNA methylation (Nilsson, Larsen et al. 2012). The sperm nucleus contains much
more than the genome (Johnson, Lalancette et al. 2011).
An alternative approach to determining how the organism as a whole may influence the genome and
whether such influences can be transmitted transgenerationally is to study cross-species clones, e.g.
by inserting the nucleus of one species into the fertilised but enucleated egg cell of another species.
Following the gene-centric view of the Modern Synthesis, the result should be an organism
determined by the species from which the genome was taken. In the great majority of cases, this does
not happen. Incompatibility between the egg cytoplasm and the transferred nuclear genome usually
results in development freezing or completely failing at an early stage. That fact already tells us how
important the egg cell expression patterns are. The genome does not succeed in completely dictating
development regardless of the cytoplasmic state. Moreover, in the only case where this process has
resulted in a full adult, the results also do not support the prediction. Sun et al (Sun, Chen et al. 2005)
performed this experiment using the nucleus of a carp inserted into the fertilised but enucleated egg
cell of a goldfish. The adult has some of the characteristics of the goldfish. In particular, the number
of vertebrae is closer to that of the goldfish than to that of a carp. This result echoes a much earlier
experiment of McLaren and Michie who showed an influence of the maternal uterine environment on
the number of tail vertebrae in transplanted mice embryos (McLaren and Michie 1958). Many
maternal effects have subsequently been observed, and non-genomic transmission of disease risk has
been firmly established (Gluckman and Hanson 2004; Gluckman, Hanson et al. 2007). A study done
in Scandinavia clearly shows the transgenerational effect of food availability to human grandparents
influencing the longevity of grandchildren (Pembrey, Bygren et al. 2006; Kaati, Bygren et al. 2007).
Epigenetic effects can even be transmitted independently of the germ line. Weaver et al showed this
phenomenon in rat colonies where stroking and licking behaviour by adults towards their young
results in epigenetic marking of the relevant genes in the hippocampus that predispose the young to
showing the same behaviour when they become adults (Weaver, Cervoni et al. 2004; Weaver 2009).
He seems to have come to the same conclusion as Eva Jablonka.
If you google search for Jablonkas paper:
Soft inheritance: challenging the modern synthesis
Abstract
This paper presents some of the recent challenges to the Modern Synthesis of evolutionary theory, which has dominated evolutionary thinking for the last sixty years. The focus of the paper is the challenge of soft inheritance - the idea that variations that arise during development can be inherited. There is ample evidence showing that phenotypic variations that are independent of variations in DNA sequence, and targeted DNA changes that are guided by epigenetic control systems, are important sources of hereditary variation, and hence can contribute to evolutionary changes. Furthermore, under certain conditions, the mechanisms underlying epigenetic inheritance can also lead to saltational changes that reorganize the epigenome. These discoveries are clearly incompatible with the tenets of the Modern Synthesis, which denied any significant role for Lamarckian and saltational processes. In view of the data that support soft inheritance, as well as other challenges to the Modern Synthesis, it is concluded that that synthesis no longer offers a satisfactory theoretical framework for evolutionary biology.
JABLONKA, Eva and LAMB, Marion J.. Soft inheritance: challenging the modern synthesis. Genet. Mol. Biol. [online]. 2008, vol.31, n.2 [cited 2013-07-16], pp. 389-395.
As you can see more and more scientists are supporting an extended evolutionary synthesis which has "Lamarckian" components. As the other user pointed out this is not knew as Gould was arguing for something similar in the 1970s but this position has now become "mainstream" I. e. many scientists are now arguing for an extended synthesis.