Tell me, It is wrong on Infection?

[Write4U]

Since virus is not alive extracellularily, no conscious mind, how can we claim infection is virus mediated?

It's a chemical language. Certain enzymes are chemical "commands". That's where "quorum sensing" comes from.

Enzymes /ˈɛnzaɪmz/
are proteins that act as biological catalysts (biocatalysts). Catalysts accelerate chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life.

Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called enzymology and a new field of pseudoenzyme analysis has recently grown up, recognising that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties.

Enzymes are known to catalyze more than 5,000 biochemical reaction types.[4] Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures.

https://en.wikipedia.org/wiki/Enzyme

Btw, do we have some evolutionary or survival purpose from virus?

Without beneficial viruses and bacteria most biological organisms would die.

Remember, the human biome is 90 % bacterial!

 

[KUMAR5]

This may shed some light on the actual mechanism. ( I won't quote, lest it creates consternation..) But viruses use the cell's own mitotic mechanism to procreate. I have a whole thread devoted to this process and the mechanics of electro/chemical information sharing in cells.

Some illustrations of cell invasion by viruses.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788752/bin/gr1.jpg
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788752/bin/gr2.jpg

Do check this out; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019765/

I need to ubderstand it deeply and technically. But grossly, it appears that it is cell/body mediated process to get virus infection not virus mediated. Ok?

 

[KUMAR5]

But it cannot multiply by itself. It must use a host's mitotic mechanism to multiply, destroying the cell in the process.

It is actually the perfect parasite, but then 90% of the human biome are bacteria and viruses. Without our symbiotic bacteria and viruses we would die.

Thanks. It suggests something different that probably our body only accept virus to infect esp intially.?

 

[Jeeves]

Since virus is not alive extracellularily, no consicious mind, how can we claim infection is virus mediated?

We don't claim that. The virus doesn't 'mediate' anything. It just happens to be present in fluid, or on surfaces where another organism can pick it up. As explained by Write4U, it can't multiply without the replicating mechanism of a more sophisticated cell.
As to whether viruses are alive in the same sense that other organisms are considered alive, it's debatable - and endlessly debated. One theory is that they are the most primitive precursors of protozoa, another is that they're the remnant of eukaryotes that were near-fatally damaged by some environmental calamity; I've even heard speculation that they're from a planet that was broken up, rode to earth in a meteorite and barely survived the landing.

Btw, do we have some evolutionary or survival purpose from virus?

Its own evolutionary purpose is the same as that of a jellyfish, a jack pine, a rhinoceros or a human: simply to continue existing.
Do we, humans get any benefit from viruses? Some of them can be useful to us, but that is not their reason for being, just as we are useful to viruses as hosts for propagating their DNA, but that is not what we evolved for. All life is interconnected and interdependent; all participants in an eco-system relate to one another in some way and the survival whole is dependent on all parts functioning within certain tolerances.
No life-form has a purpose, other than the short-term goals it sets for itself.

 

[KUMAR5]

This may shed some light on the actual mechanism. ( I won't quote, lest it creates consternation..) But viruses use the cell's own mitotic mechanism to procreate. I have a whole thread devoted to this process and the mechanics of electro/chemical information sharing in cells.

Some illustrations of cell invasion by viruses.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788752/bin/gr1.jpg
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788752/bin/gr2.jpg

Do check this out; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019765/

It is quite technical. But apparently does it not suggest intracellular processes for viral movements, replication etc?
First, I want to understand fusion and internalization of virus via ACE2. What make to affect it? Actually, if it is cell/body mediated
we shall need to target cell/body processes instead of direct attack on Virus?

 

[KUMAR5]

But it cannot multiply by itself. It must use a host's mitotic mechanism to multiply, destroying the cell in the process.

It is actually the perfect parasite, but then 90% of the human biome are bacteria and viruses. Without our symbiotic bacteria and viruses we would die.

Yes but it is intracellular process. I am first checking extracellular processes i.e. fusion and internalization---if cell/host mediated or virus mediated. If it is cell/host mediated, logically, we need to target cell/host system otherwise virus. Some anti-virals are also there which can target cell/host mechanisms and at basic level. Already quoted.

 

[KUMAR5]

ne against ACE2

It's a chemical language. Certain enzymes act as "commands". This is where the term "quorum sensing" originated https://en.wikipedia.org/wiki/Enzyme

Then, it will instead be cell/host mediated not virus mediated. Not so? If yes, we need to instead target cells/host processes responsible for it. I read one Vaccine whicg targetted ACe2 was tried but not then pursued.

 

[KUMAR5]

We don't claim that. The virus doesn't 'mediate' anything. It just happens to be present in fluid, or on surfaces where another organism can pick it up. As explained by Write4U, it can't multiply without the replicating mechanism of a more sophisticated cell.
As to whether viruses are alive in the same sense that other organisms are considered alive, it's debatable - and endlessly debated. One theory is that they are the most primitive precursors of protozoa, another is that they're the remnant of eukaryotes that were near-fatally damaged by some environmental calamity; I've even heard speculation that they're from a planet that was broken up, rode to earth in a meteorite and barely survived the landing.

Its own evolutionary purpose is the same as that of a jellyfish, a jack pine, a rhinoceros or a human: simply to continue existing.
Do we, humans get any benefit from viruses? Some of them can be useful to us, but that is not their reason for being, just as we are useful to viruses as hosts for propagating their DNA, but that is not what we evolved for. All life is interconnected and interdependent; all participants in an eco-system relate to one another in some way and the survival whole is dependent on all parts functioning within certain tolerances.
No life-form has a purpose, other than the short-term goals it sets for itself.

The whole sense of doubting is that it is also considered as non-alive extracellular. We can not base it's mediation to infect. Hence we may instead need to target cell/host processes to check it.

 

[KUMAR5]

[A question to relax] unquote.

If you restrict a thief not to touch your main door and not allw his entry into your home or if already entered
throw him/them out of home and then resist his/their re-entry, can he harm you?

 

[Write4U]

we shall need to target cell/body processes instead of direct attack on Virus?

I think that is one of the various possible approaches. I like the idea of inhibiting quorum sensing .

 

[Write4U]

[A question to relax] unquote.

If you restrict a thief not to touch your main door and not allw his entry into your home or if already entered
throw him/them out of home and then resist his/their re-entry, can he harm you?

He cannot harm you anyway, not until there is a quorum which triggers the virulence.

 

[Jeeves]

The whole sense of doubting is that it is also considered as non-alive extracellular. We can not base it's mediation to infect. Hence we may instead need to target cell/host processes to check it.

I have no idea what you're on about.

 

[Write4U]

The whole sense of doubting is that it is also considered as non-alive extracellular. We can not base it's mediation to infect. Hence we may instead need to target cell/host processes to check it.

That's what we do with cancerous cells, no? Not very gentle on the host.

If you mean there is no "intent' you're right. Intent is not required. Its a chemical process. The communication is via chemistry. All we need to do is to confound the language and the virus remains benign.

Abiogenesis does not require motive or intent. It's a mathematical electro-chemical function . The virus is a transitional organism. Actually, it is thought that the virus devolved from a common ancestor with the bacteria, which was able to copy itself.

 

[KUMAR5]

He cannot harm you anyway, not until there is a quorum which triggers the virulence.

When it can replicate or form its own quorum, how can we say, it can not harm?

 

[KUMAR5]

I have no idea what you're on about.

Do virus infect a dead person?

 

[KUMAR5]

That's what we do with cancerous cells, no? Not very gentle on the host.

If you mean there is no "intent' you're right. Intent is not required. Its a chemical process. The communication is via chemistry. All we need to do is to confound the language and the virus remains benign.

Abiogenesis does not require motive or intent. It's a mathematical electro-chemical function . The virus is a transitional organism. Actually, it is thought that the virus devolved from a common ancestor with the bacteria, which was able to copy itself.

Yes, it receptor mediated fusion( also internalization). Then, should we first not target these two...fusion and internalization at basic level? Some drugs are already there in application...need to be carefully studied specifically and re-purposed. Already quoted.

 

[Write4U]

Do virus infect a dead person?

Maybe for a couple of hours as the cells begin to die. When decay sets in, that is from a different competing virus or bacteria. btw. Some viruses use bacteria to procreate.

How long HIV virus survive in a Dead Human body

Once the virus leaves the human body, it dies within minutes, since the virus is immediately going into an environment in which it cannot survive. Inside a dead body, the changes to the viruses environment occur gradually, which is why HIV will survive for longer periods of time.

www.thebody.com/article/long-hiv-virus-survive...

 

[Write4U]

When it can replicate or form its own quorum, how can we say, it can not harm?

Not until a quorum is reached. That's the beauty. We can prevent the bacteria or viruses from reaching a quorumb by chemical language. We need to learn the language !

But the cure; no virulence, no procreation and the virus dies by natural selection without acquiring immunity.

 

[Write4U]

This may be of interest;

 

[Write4U]

And for good measure;