One thing that could throw a wrentch in the possibility of this all being a simulation is the possibility that there are fundamentals to this universe which are not integers, all simulation must use integers for all value: there is only so many decimal points of accuracy.
..I am not certain that there is even 1 thing, in reality, that would ALLOW the possibility of this all being a simulation - just about anything and everything else in existence throws a "bagful of wrenches" into the "at all possible machine"...