Tell me, It is wrong on Infection?

[KUMAR5]

Hello,
Greetings!!

One area is exposed to some new pathogenic Virus. Initially, few people ought to get low grade sub-clinical infection.
Being low grade host's immune system is able to treat that and develop immunological memory or natural
immunity against it. Then on 2nd bigger infection immune system is able to deal with it. So that infection
will be cured.

Now suppose we bye-pass this Ist low grade exposure by aggressively avoiding it and directly exposed
to 2nd bigger grade infection. WHAT WLL BE THE RESULT??

[ say for example COVID-19 ]

Best wishes.

 

[Seattle]

Hello,
Greetings!!

Why must the first wave consist of low grade sub-clinical infections? That's not what is happening with Covid-19. Many people are dying.

If you want to imagine that the second wave will be much worse and more people would be immune had we let everyone get it...that's one scenario. Who knows if it is the real scenario?

SO WE DON"T KNOW WHAT THE RESULTS WOULD BE!

Best wishes.

 

[KUMAR5]

Thanks.

Initially, very few people were infected which multiplied later.

That was l0w grade or low scale, we need to see.

Anyway, every or most ones tried best to avoid low grade or low scale infection.

So, can not claim, that Naturally acquired active immunity is used.

Naturally acquired active immunity[edit]
Further information: Immune system
Naturally acquired active immunity occurs when a person is exposed to a live pathogen and develops a primary immune response, which leads to immunological memory.[9] This type of immunity is "natural" because deliberate exposure does not induce it. Many disorders of immune system function can affect the formation of active immunity such as immunodeficiency (both acquired and congenital forms) and immunosuppression.
https://en.wikipedia.org/wiki/Immunity_(medical)

 

[KUMAR5]

Hello,
Greetings!!

Why must the first wave consist of low grade sub-clinical infections? That's not what is happening with Covid-19. Many people are dying.

If you want to imagine that the second wave will be much worse and more people would be immune had we let everyone get it...that's one scenario. Who knows if it is the real scenario?

SO WE DON"T KNOW WHAT THE RESULTS WOULD BE!

Best wishes.

....2. Moreover, there may be no way to check low grade sub-clinical infection unless antibodies or
immunological memory is developed by Ist wave low grade infection by say Vaccine effect. When Plasma
Therapy is anticipated, it can mean, antibodies are developed on infection. Ok?

 

[Seattle]

OK.

 

[Jeeves]

One area is exposed to some new pathogenic Virus. Initially, few people ought to get low grade sub-clinical infection.
Being low grade host's immune system is able to treat that and develop immunological memory or natural
immunity against it. Then on 2nd bigger infection immune system is able to deal with it. So that infection
will be cured.

Now suppose we bye-pass this Ist low grade exposure by aggressively avoiding it and directly exposed
to 2nd bigger grade infection.

You got the information on the immune system from wikipedia?
It's referring, in a general context, to type of immune response that an individual might develop.
It doesn't necessarily apply to all humans or all infectious diseases, and certainly makes no reference to the present pandemic. You could spend a lot more time reading up on epidemiology.

So, can not claim, that Naturally acquired active immunity is used.

and that's probably why nobody who understands anything is claiming that.

 

[KUMAR5]

You got the information on the immune system from wikipedia?
It's referring, in a general context, to type of immune response that an individual might develop.
It doesn't necessarily apply to all humans or all infectious diseases, and certainly makes no reference to the present pandemic. You could spend a lot more time reading up on epidemiology.

and that's probably why nobody who understands anything is claiming that.

 

[KUMAR5]

Thanks. Do you mean that we do not acquire natural active immunity on once getting infected to COVID-19 virus? If this is the case then, 1. Anyone can be re-infected again n again even after first infection 2. Vaccine for it may not be possible. 3. Immunological memory and antibody development against this virus is not developed and if so 4. How plasma therapy can work for this infection?

 

[KUMAR5]

OK.

This question is also need to be addressed, how many infected got cured without proper medicine?

 

[KUMAR5]

Is there a blood (serology) test for COVID-19?
Scientists have recently developed blood tests that detect antibodies produced by the immune system in response to a SARS-CoV-2 infection, but these are not widely available yet. These serology tests detect IgG and IgM antibodies and will be useful in determining who has had COVID-19 in the past even though they might not have noticed any signs or symptoms and/or were not previously tested. These antibody tests also might be useful in determining who may be immune to the infection. However, they likely won’t be useful in diagnosing acutely ill patients because it can take several days for antibodies to develop and be detectable in the blood. https://labtestsonline.org/news/laboratories-working-expand-covid-19-testing

Look at above. It may suggest involvement of naturally acquired active immunity.

 

[DaveC426913]

Kumar, I'm not sure what you're trying to tell us.

Yes, our body will presumably build its own antibodies to ward off Covid-19 - after a while.

But that takes time, and requires you to get infected in the first place.
People are getting infected and are dying before their immune systems can fight it off - or it is so virulent that it overwhelms the body's defenses.

The trick is to weaponize it, so that it can be used preemptively on those not yet infected, to stop the infection in its tracks.

 

[billvon]

1. Anyone can be re-infected again n again even after first infection

Correct. That's possible, and it has been observed.

2. Vaccine for it may not be possible.

Correct.

3. Immunological memory and antibody development against this virus is not developed

That does not follow from the above. You may mount an antibody response, but your memory T-cells may not be able to hold the immunologic memory.

4. How plasma therapy can work for this infection?

Because antibodies still work against it.

 

[KUMAR5]

Hello Dave,
The main sense of my OP is to understand that whether our body is equipped with such a immune response that it can develop natural active immunity against this virus or not, may be bit later after getting ist wave of low grade infection? In other sense, van we get natural vaccination effect or not after ist exposure? What do you mean by, it is so virulent...... Does it mean in acute stage or even after antibodies are developed?

 

[KUMAR5]

... 2 otherway, I also want to understand pros n cons related to newly opted aggressive means of its avoidance esp on initial exposure... i. e. by social distancing, avoidance n hygienes.

 

[KUMAR5]

Correct. That's possible, and it has been observed.

Correct.

That does not follow from the above. You may mount an antibody response, but your memory T-cells may not be able to hold the immunologic memory.

Because antibodies still work against it.

Do you mean this virus is so viruluent that even it overwhelms developed natural active immunity after first infection?
If so, how plasma therapy can work?

 

[billvon]

Do you mean this virus is so viruluent that even it overwhelms developed natural active immunity after first infection?

No. I am saying that if you mount an adaptive immune response, it might well clear the infection. But if your memory T-cells do not retain the immunologic memory of the response, then you do not have any immunity going forward. As soon as the antibodies clear your blood you are susceptible again.

If so, how plasma therapy can work?

Plasma therapy relies on antibodies.

 

[Jeeves]

I'm not an immunologist or epidemiologist; I don't have definitive answers.

Do you mean that we do not acquire natural active immunity on once getting infected to COVID-19 virus?

Too soon to tell.

If this is the case then, 1. Anyone can be re-infected again n again even after first infection

Possibly. Viruses and bacteria adapt far more quickly than humans do. Covid-19 is a novel strain of corona virus that has not been studied in humans before. It appears to mutate even more rapidly than other members of its family, and it's possible that people who have been infected by one generation of Covid-19 will not be immune to future variants.

2. Vaccine for it may not be possible.

They'll certainly produce a vaccine. It may turn out to be ineffective, or partially or selectively effective.
It's also possible (I get the impression it's starting to look probable) that people who recover from the illness continue to have some of the virus in their system; it may go dormant and undetected by such tests as we currently have available. Of course, the virologists will continue to develop more accurate tests.

3. Immunological memory and antibody development against this virus is not developed

Maybe.

4. How plasma therapy can work for this infection?

It may not.
Medical science proceeds by trying every method that might work, then discarding the ones that don't and further developing the ones that either do or could.

 

[Jeeves]

... 2 otherway, I also want to understand pros n cons related to newly opted aggressive means of its avoidance esp on initial exposure... i. e. by social distancing, avoidance n hygienes.

You're considering two different issues.
The avoidance policy is not for individual to develop resistance to the virus. It's to prevent everybody being sick at the same time.
This virus makes some people only a little bit sick and some people very, very sick. The very sick ones need intensive medical care. The health-care system is designed to treat a limited number of very sick people at any one time. If too many people get sick at once, most of them will die, because there isn't enough hospital space and equipment to help them all. So we try to have the smallest possible number very sick in any given week.
Maybe in the next three years, everybody in the world will catch it, but most of us will get the help we need and recover.

 

[KUMAR5]

You're considering two different issues.
The avoidance policy is not for individual to develop resistance to the virus. It's to prevent everybody being sick at the same time.
This virus makes some people only a little bit sick and some people very, very sick. The very sick ones need intensive medical care. The health-care system is designed to treat a limited number of very sick people at any one time. If too many people get sick at once, most of them will die, because there isn't enough hospital space and equipment to help them all. So we try to have the smallest possible number very sick in any given week.
Maybe in the next three years, everybody in the world will catch it, but most of us will get the help we need and recover.

Thanks.

Actually, aggressive avoidance policy is right subject to fact that this virus is so virulent that we do not develop natural active immunity against it or for reasons you indicated above. Developing Resistance is not an issue here.

 

[KUMAR5]

No. I am saying that if you mount an adaptive immune response, it might well clear the infection. But if your memory T-cells do not retain the immunologic memory of the response, then you do not have anO

Plasma therapy relies on antibodies.

Okay, developing antibodies and immunological memory are two separate physiology. ?

ping