In fact, no beneficial mutation has ever actually been observed.
I went to pubmed and oh boy. I didn't even need to scroll. Second article already showed beneficial mutations. And I was actually looking for something else. Just out:
Mol Biol Evol. 2007 Feb 24; [Epub ahead of print]
Chromosome Rearrangements and the Evolution of Genome Structuring and Adaptability.
Eukaryotes appear to evolve by micro and macro rearrangements. This is observed not only for long-term evolutionary adaptation, but also in short-term experimental evolution of yeast, S. cerevisiae. Moreover, based on these and other experiments it has been postulated that repeat elements, retroposons for example, mediate such events. We study an evolutionary model in which genomes with retroposons and a breaking/repair mechanism are subjected to a changing environment. We show that retroposon-mediated rearrangements can be a beneficial mutational operator for short-term adaptations to a new environment. But simply having the ability of rearranging chromosomes does not imply an advantage over genomes in which only single gene insertions and deletions occur. Instead, a structuring of the genome is needed: genes that need to be amplified (or deleted) in a new environment have to cluster. We show that genomes hosting retroposons, starting with a random order of genes, will in the long run become organized, which enables (fast) rearrangement-based adaptations to the environment. In other words, our model provides a "proof of principle" that genomes can structure themselves in order to increase the beneficial effect of chromosome rearrangements.
or here:
Pattern of nucleotide substitution and divergence of prophenoloxidase in decapods
Fish & Shellfish Immunology
Volume 22, Issue 6 , June 2007, Pages 628-640
Despite the unprecedented development in identification and characterization of prophenoloxidase (proPO) in commercially important decapods, little is known about the evolutionary relationship, rate of amino acid replacement and differential selection pressures operating on proPO of different species of decapods. Here we report the evolutionary relationship among these nine decapod species based on proPO gene and types of selective pressures operating on proPO codon sites. Our analyses revealed that all the nine decapod species shared a common ancestor. The mean percentage sequence divergence at proPO gene was 34.4 ± 0.6%. Pairwise estimates of nonsynonymous to synonymous ratio (ω) for Homarus americanus–H. gammarus is greater than one, therefore indicating adaptive evolution (functional diversification) of proPO in these two species. In contrast, strong purifying selection (ω < 1) was observed in all other species pairs. However, phylogenetically closely related decapods revealed relatively higher ω value (ω = 0.15 ± 0.3) than the distantly related species pairs (ω = 0.0075 ± 0.005). These discrepancies could be due to higher fixation probability of beneficial mutationnext term in closely related species. Maximum likelihood-based codon substitution analyses revealed a strong purifying selection operating on most of the codon sites, therefore suggesting proPO is functionally constrained (purifying selection). Codon substitution analyses have also revealed the evidence of strong purifying selection in haemocyanin subunits of decapods.
or here:
J.J. Bull, M.R. Badgett and H.A. Wichman, Big-benefit mutations in a bacteriophage inhibited with heat, Mol Biol Evol 17 (2000), pp. 942–950.
or here:
Nature Reviews Genetics 4, 457-469 (2003); doi:10.1038/nrg1088
EVOLUTION EXPERIMENTS WITH MICROORGANISMS: THE DYNAMICS AND GENETIC BASES OF ADAPTATION
ore here:
PNAS | June 20, 2000 | vol. 97 | no. 13 | 6981-6985
Bacteria are different: Observations, interpretations, speculations, and opinions about the mechanisms of adaptive evolution in prokaryotes
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