Cranberries and Cancer Prevention

S.A.M.

S.A.M.

uniquely dreadful
Valued Senior Member
A new research review and study examines how cranberry's unique flavonoid compounds -- which act as potent antioxidants -- have been further linked to potential anti-cancer properties. Led by Dr. Catherine C. Neto of the University of Massachusetts Dartmouth and funded in part by the Cranberry Institute and the Wisconsin Cranberry Board, this review is the first to examine the effects of cranberry polyphenols on human cancer cells, in order to further explore cranberry's potential role in cancer prevention. The review was published in the current edition of The Journal of Nutrition and presented as a part of the International Research Conference on Food, Nutrition, and Cancer, hosted by the American Institute of Cancer Research in Washington, D.C. in July 2006.

The review explores the existing research and recent findings on the anti-cancer properties of the cranberry, and its diverse phytochemical profile that likely plays a role in cancer prevention. Cranberries' high antioxidant content is one of the many factors that work synergistically to create observed anti-tumor activities. "The results from in vitro studies using a variety of tumor models show that the polyphenol extracts from cranberry inhibit the growth and spread of breast, colon, prostate, lung, and other tumors," said Dr. Neto.

"This review is so significant because it adds to the growing body of evidence of both the proven and emerging health benefits of the cranberry," said Martin Starr, PhD, science advisor to the Cranberry Institute.

The cranberry has long been recognized for its potential health benefits, from prevention of urinary tract infections and gum disease via a unique anti-adhesion mechanism, to its high level of antioxidants, which may also provide protection from cardiovascular disease. These new findings reinforce earlier research on cranberry's anti-cancer benefits and show promise that cranberry may limit processes involved in tumor development and growth in human patients.

In a recent study published in the Journal of Agriculture and Food Chemistry, researchers at the University of California, Los Angeles tested the extracts of six berries, including cranberry, against human tumor cell lines in cell cultures. Cranberry extract was shown to be effective in slowing cancer cell growth, a protective benefit that increased with the amount of extract added.
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http://www.wisbusiness.com/index.iml?Article=86888
 
How mutations in cancer cells can be reversed? Without it or without killing those cells, how cancer can be treated?
 
Kumar said:
How mutations in cancer cells can be reversed? Without it or without killing those cells, how cancer can be treated?
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Mutations cannot be reversed, but some phytochemicals have anti-proliferative effects and help delay the progression of cancers. Others have anti-oxidant effects and prevent the formation of free radicals which can result in DNA damage and mutations.
 
Genji:

Glad to see you're a fan.

SamCDKey:

Are you sure on the "mutations cannot be reversed" bit?

Diabetes is caused by a mutation and can be completely cured by a period of strict dieting.
 
Prince_James said:
Genji:

Glad to see you're a fan.

SamCDKey:

Are you sure on the "mutations cannot be reversed" bit?

Diabetes is caused by a mutation and can be completely cured by a period of strict dieting.
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Controlling the symptoms is very different from ameliorating the causes.
 
SamCDKey:

I am fairly certain diabetes can be outright cured through such plans. I even know someone who was once a full fledged diabetic, but now is no longer such.
 
Prince_James said:
SamCDKey:

I am fairly certain diabetes can be outright cured through such plans. I even know someone who was once a full fledged diabetic, but now is no longer such.
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There are several different kinds of diabetes, the diagnosis is symptomatic based on postprandial hyperglycemia following an oral glucose tolerance test, so the causes are many and varied.

Some types of diabetes are easy to control but require maintenance of weight and dietary regimens for optimal results. Others require hypoglycemics or insulin.
 
It was in reference to SamCDKey saying it was not a true cure of Diabetes, which I say it is.
 
DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as UV light can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day...

The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. A cell that has accumulated a large amount of DNA damage, or one that no longer effectively repairs damage incurred by its DNA, can enter one of three possible states:

1. an irreversible state of dormancy, known as senescence
2.cell suicide, also known as apoptosis or programmed cell death
3.unregulated cell division, which can lead to the formation of a tumor that is cancerous

http://en.wikipedia.org/wiki/DNA_repair
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What can be done in case of cancer?

Whether stimulating apoptosis is possible? Can hypotonic or hypertonic environment effect normal apoptosis, cell shrinkage etc.?

Can cancer be more common in heavy drinker of water?
 
samcdkey said:
Mutations cannot be reversed, but some phytochemicals have anti-proliferative effects and help delay the progression of cancers. Others have anti-oxidant effects and prevent the formation of free radicals which can result in DNA damage and mutations.
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It can slow the progress but can't reverse. Who will take chance?

Whether free radicals or oxidative stress can be related to Apoptosis?
 
besides, cranberries are good. /me munches on his cranberry/blueberry/white rasin dried fruit mixture.

yummy.
 
Cranberries anti-cancer properties may have something to do with the fact that they are moderately high in Nitrilisides or Nitriles.

The Hunza people of northern Pakistan are known to be more or less cancer free possibly due to their diet. The large number of apricot kernels they eat contain huge amount of nitrilisides.

This LONG documentary explains the theory:
http://www.youtube.com/watch?v=Xh2od6q7lD8
 
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