Yes, because you were rather insolently sending me off somewhere else to go & do your homework for you. Ask specific questions. Think, don't just link.Well that was an easy out!
Yes, because you were rather insolently sending me off somewhere else to go & do your homework for you. Ask specific questions. Think, don't just link.Well that was an easy out!
Which only tremendously exacerbates the situation for unguided abiogenesis since the specific folding sequence requirements greatly increase the improbability of chance occurrence. And if you retort 'it wasn't just chance' than please offer a believable explanation as to where and how an effective level of non-chance arose naturally.Yes, the simplest ribozymes are indeed of the order of only ~50 nucleotides long, but their ribozymic chemical activity depends on them being able to fold just right.
I thought it obvious. To take the last point - without specific information content acting ab initio there is no self-replication. Chicken & egg in my book.On the second matter, you don't make any sense. Quoi?
You really took it like that?Yes, because you were rather insolently sending me off somewhere else to go & do your homework for you.
And that piece was not actual insolence? My we have hit it off on a bad note.Ask specific questions. Think, don't just link.
Yes, the 3D folding of oligomers explores a vast array of conformational space, in which one wouldn't be surprised to find that some of the molecular conformations (stumbled-across blindly, by chance) are at lower total chemical potential energies (& hence more stable & time-persistent) than others, & similarly for ribozymic activities to be found, again by chance.Which only tremendously exacerbates the situation for unguided abiogenesis since the specific folding sequence requirements greatly increase the improbability of chance occurrence. And if you retort 'it wasn't just chance' than please offer a believable explanation as to where and how an effective level of non-chance arose naturally.
I thought it obvious. To take the last point - without specific information content acting ab initio there is no self-replication. Chicken & egg in my book.
Yes, the whole posture of your welcoming of a newbie on here has been less than pleasant. But as you can see, you've failed so far to scare off, dissuade, or bully me. Now one can hope that we can have discourse more respectfully.You really took it like that?
And that piece was not actual insolence? My we have hit it off on a bad note.
That's it? Well if lower chemical potential is the chief natural driver, the thermodynamic tendency will be for hydrolysis and fragmentation of long peptide chains, or better yet, Maillard-type side reactions thwarting long chains ever forming in the first place.Yes, the 3D folding of oligomers explores a vast array of conformational space, in which one wouldn't be surprised to find that some of the molecular conformations (stumbled-across blindly, by chance) are at lower total chemical potential energies (& hence more stable & time-persiatent) than others, & similarly for ribozymic activitiea to be found, again by chance.
And how can initial random informationless sequences ever realistically escape that vicious cycle? One needs a lot of specific information for self-replication to kick in, no?Your second point, your book is simply in plain error, as you're fixating too early on informational content. Informational theory would say that the first incipiently biopoietic oligomers would be expected to have been of random sequence and thus informationless.
If that's how you want to construe it, nothing much else to say really.But as you can see, you've failed so far to scare off, dissuade, or bully me.
On your first point, you're wrong because you clearly haven't appreciated the elementary structural importance of (esp. intramolecular) cooperativity among weak chemical bonds (esp. Hydrogen bonding, of course).That's it? Well if lower chemical potential is the chief natural driver, the thermodynamic tendency will be for hydrolysis and fragmentation of long peptide chains, or better yet, Maillard-type side reactions thwarting long chains ever forming in the first place.
And how can initial random informationless sequences ever realistically escape that vicious cycle? One needs a lot of specific information for self-replication to kick in, no?
Yes, evidently an apology and a kind word of welcome to a newbie on here were indeed too much to have hoped for.If that's how you want to construe it, nothing much else to say really.
Wrong and wrong you say. Got any specific and relevant examples backing each assertion above?On your first point, you're wrong because you clearly haven't appreciated the elementary structural importance of (esp. intramolecular) cooperativity among weak chemical bonds (esp. Hydrogen bonding, of course).
On your second point, you're wrong because you seem to think that a lot of information's required for the first-ever kind of ribozymic-type of chemical activity to have been stumbled-across, by pure chance, in & amongst the enormous sequence & higher-order structural spaces available.
You come across as thin skinned, but of a type not afraid to dish it out to others. Imagining insults where none was implied. And still have no idea of how much outright crudeness and irreverence and vindictiveness passes for the norm here.Yes, evidently an apology and a kind word of welcome to a newbie on here were indeed too much to have hoped for.
Do you have anything beyond Grade 10 Science?Wrong and wrong you say. Got any specific and relevant examples backing each assertion above?
Yes. I agree that I'm evidently old-fashioned in that I expect decency. Truly, has no other person in either virtual or real life ever told you that you come across too brusquely, dismissively, & rudely?You come across as thin skinned, but of a type not afraid to dish it out to others. Imagining insults where none was implied. And still have no idea of how much outright crudeness and irreverence and vindictiveness passes for the norm here.
Your response in previous post marks your current post one of hypocrisy. I think we are done conversing here.Yes. I agree that I'm evidently old-fashioned in that I expect decency. Truly, has no other person in either virtual or real life ever told you that you come across too brusquely, dismissively, & rudely?
Yes I know how passionately you hate the notion of a god.
You make an absolute pronouncement there re 'no evidence' that imo is totally unwarranted.
You are entitled to your opinion Alex but it would be safer and more accurate to include 'imo' when making such pronouncements. I invite you to take up the challenge of spending all of 50 minutes actually viewing and objectively assessing that vid I linked to elsewhere but reproduce here:No I hate people making stuff up and presenting it as real with no evidence..Clearly all gods are a human invention the god of the bible invented in Sumeria... JC another in the long procession of human gods modelled upon astrology...there is no evidence of super natural and speculation that it exists is mere speculation ...
I have never seen any evidence so my pronouncement is not unwarranted...you could prove me uninformed with just one piece of evidence that proves I am wrong.
I have asked for evidence and it has never been provided in the past...I look on the net and can't find any.
Anyways is this thread given your input not better in the religion section...
Alex
If you decline these invitations to actually seriously study material contra to your position, ask yourself how reasonable and secure is your philosophical outlook. Cheers.