Carcinogenicity[edit]
In 2015, the
International Agency for Research on Cancer classifies DDT as Group 2A "probably carcinogenic to humans".
[85] Previous assessments by the U.S.
National Toxicology Program classified it as "reasonably anticipated to be a carcinogen" and by the EPA classified DDT, DDE and DDD as class B2 "probable"
carcinogens; these evaluations were based mainly on animal studies.
[1][38]
A 2005 Lancet review stated that occupational DDT exposure was associated with increased
pancreatic cancer risk in 2 case control studies, but another study showed no DDE dose-effect association. Results regarding a possible association with
liver cancer and biliary tract cancer are conflicting: workers who did not have direct occupational DDT contact showed increased risk. White men had an increased risk, but not white women or black men. Results about an association with multiple myeloma, prostate and testicular cancer, endometrial cancer and colorectal cancer have been inconclusive or generally do not support an association.
[38] A 2017 review of liver cancer studies concluded that "organochlorine pesticides, including DDT, may increase
hepatocellular carcinoma risk."
[86]
A 2009 review, whose co-authors included persons engaged in DDT-related litigation, reached broadly similar conclusions, with an equivocal association with testicular cancer. Case–control studies did not support an association with leukemia or lymphoma