Vaccine Thwarts The Tangles Of Alzheimer's

kangarian

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A new study by NYU Medical Center researchers shows for the first time that the immune system can combat the pathological form of tau protein, a key protein implicated in Alzheimer's disease.

The researchers, led by Einar Sigurdsson Ph.D., Assistant Professor of Psychiatry and Pathology at New York University School of Medicine, created a vaccine in mice that suppresses aggregates of tau.

The protein accumulates into harmful tangles in the memory center of the brains of Alzheimer's patients.

The vaccine successfully slowed the deterioration of motor abilities produced by excessive amounts of tau in the central nervous system of mice, according to the study published in the August 22, 2007 issue of the Journal of Neuroscience. Dr. Sigurdsson plans to conduct follow-up studies using mice that slowly develop tangles and cognitive impairments without movement problems.

Note: This story has been adapted from a news release issued by New York University Medical Center and School of Medicine.
 
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That’s really interesting, thanks.

The “bundled” version of Tau is a key protein implicated in Alzheimer's disease, but it is also a ubiquitous neuronal protein. I haven’t read the article in question yet, but this vaccine will have to somehow prime the immune system to recognize the disease form of the protein but not the normal version.
 
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