Trinucleotide repeat disorders

[Jake Arave]

I've been spending the last 5-6 weeks studying CAG related disorders, namely Huntington's Disease. I've had a nagging question that I couldn't seem to find the answer to, and that question is: "What is the genomic component that is universal among all CAG-repeat disorders?" We know that they are dominantly inherited, and each offspring has a 50/50 chance to receive Huntington's Disease but what is the actual 'cause' of the disease? What makes these repetitions inheritable? Any and all insight is helpful into developing my knowledge. Thanks!

 

[Jake Arave]

Found the information I needed.

 

[GeoffP]

Glad we could help.

 

[James R]

What will I do when I need that information?

Please tell me, Jake, so I don't have to do the leg work.

 

[Jake Arave]

What will I do when I need that information?

Please tell me, Jake, so I don't have to do the leg work.

Found it through various medical journals - I can't remember the exact names but it's out there if you search hard enough.

 

[James R]

Well, this thread isn't as useful as it could have been...

 

[Jake Arave]

Well, this thread isn't as useful as it could have been...

I could answer most questions you have - without citation of course. If there is anything you need to know, just message me.