Much cheaper means of bringing bulk cargo and people to orbit.
I'm a big fan of the Space Elevator. "Hard" sci-fi writers--real scientists who try to make their fiction plausible--seem to be telling us that this idea is practical. We might be able to start planning the project right now without any advances in science and engineering. The biggest problem is undoubtedly security: How can we protect a project that large, with such a huge, international staff, from the next gaggle of religious wackos? And of course the second problem is economic. There is still a huge contingent of humanity who don't want us "wasting" resources on space flight. Perhaps if we give them all jobs building the elevator they'll shut up. I'm sure most of them would at least be qualified to clean the latrines or even run the commissary.
Much better power sources for spacecraft.
How much nuclear fuel would a craft have to carry in order to maintain one-gee acceleration for half the trip and one-gee deceleration for the other half? That would get a ship to Alpha Centauri within the crew's working lifetime, and--without doing the math--maybe even home again. Alternately, what fraction of c must a ship attain before it starts sucking up enough interstellar hydrogen to fire up a Bussard ramjet? Would that reduce the size of the nuclear fuel tank to something manageable and get the ship there while the crew is still alive?
I can't help but think that solving these two problems might make spaceflight feasable enough that SOME economic gain may come from spaceflight, driving such developments as maybe interstellar travel.
It's difficult to envision the economic gain from spaceflight. People want an ROI in their own lifetime and Americans want it in this fiscal quarter. Within that time frame we can't bring back exotic cultural artifacts and solutions to our philosophical questions from the nearest civilized planet, much less send even the wealthiest vacationers to their beach resorts. We probably can't even bring back animal and plant life that quickly from the nearest planet that has it to create new medicines or just introduce more lovable invasive species to our gardens and waterways. We can't even start a viable, self-supporting colony on the nearest uninhabited planet with a vaguely compatible environment, which would be Mars. Don't even think about the cost-effectiveness of shipping minerals home, even if we find fifty-carat tsavorites lying on the ground on Titan.
Man on alpha-centauri in this century? No way, not without another space-race, and it'd have to be a fast-paced one at that. Like if earth was due to just suddenly blow up in 2099 or something.
Earth is destined to lose a frighteningly large part of its most heavily developed real estate sometime around 2099 due to a rise in sea level, and we can't even get people out of their SUVs. The best we can do is hold a huge multinational party with a lot of popular entertainers, and the most influential celebrity we can get to host it is Al Gore.
Disclaimer: I'm just a dreaming aerospace-engineering student with no industry experience, so I might be thinking way too optimistically
I don't think industry is your problem, it's sociology.
I would think that another type of math and engineering will be needed in order to travel to another solar system. The current scientific views seem to say that we won't be able to travel through our galaxy but if another genius like Einstien comes along and changes the way we look at math than anything could be possible at anytime.
The 19th century was the century of chemistry. Nothing we've learned about chemistry since then has really turned science upside down. Similarly, the 20th century was the century of physics. It's not looking like string theory and electrons communicating over long distances and all the next generation of discoveries are going to turn physics upside down like subatomic particles, relativity and the Heisenberg Principle did. People who make it their business to think about such things tell us that this will be the century of biology and that we'll probably have to go to the stars with the physics we've got. Einstein didn't change the way we looked at physics (not math), so much as he developed a theory that explained puzzling new observed data. Where's the puzzling new observed data to inspire the next quantum leap--or Quantum Theory? It's all in biology. Obviously they can all be wrong.
Sure I believe we'll see it happen before the death part interplays. There's steps to reaching the stars the first step is free energy. And I think we'll see that soon, at least in another decade. After the first step is done anything is possible. Well almost anything.
Free energy in ten years? Don't tell that to the SUV owners! Don't forget that every time we think we've found an inexhaustible new supply of something we simply increase our consumption of it by several orders of magnitude until we prove that it was finite after all. Land to expand into, fossil fuels, oceans to fish, places to dump trash. Even utopianist Gene Roddenberry acknowledged this when Captain Picard discovered that "hyperspace" is not an inexhaustible resource.