Phase II HapMap contains three times more markers than the initial version and now enables researchers to focus their gene searches more precisely on specific regions of the genome. It is now completed.
Go to: "International HapMap Project" at
http://www.hapmap.org/ and click on Bulk Download at
http://www.hapmap.org/downloads/index.html.en - "This release contains all processed data from phases I+II of the project."
2006-07-20: HapMap Public Release #21:
Genotypes, frequencies and assays for phase I and phase II of the HapMap project are now available for bulk download. The files contain all phase I and II data combined. This release contains all processed data from the HapMap project, and includes all data from phases I+II of the project. This release also contains genotypes from the Affymetrix 500k genotyping array. In addition to expressing the genotypes relative to the dbSNP rs sequence, this release contains a set of files expressing genotypes relative to the forward strand of NCBI build 35. The genotypes are identical, and are complement for SNPs where the rs sequence maps to the reverse strand of the genome build. The phased genotypes are expressed relative to the forward strand of build 35, so the displayed alleles will read as a haplotype across a single strand along the chromosome."
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"Phase II" HapMap will take advantage of the rapid, high-throughput genotyping capacity of Perlegen Sciences, Inc., of Mountain View, Calif., to test another 4.6 million SNPs from publicly available databases, and add that information to the map. As a result of a grant competition last summer, Perlegen received a $6.1 million award from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), to add data on 2.25 million additional SNPs to HapMap. The new development, enabled by a partnership among multiple funding sources, will expand that effort and test virtually the entire known catalog of human variation on the HapMap samples. This will increase the density of SNP "signposts" across the genome from the current average of one every 3,000 bases to about one every 600 bases."
http://www.eurekalert.org/pub_releases/2005-02/nhgr-ihc020705.php
