To live indefinitely is a dream as old as mankind itself. The idea of immortals dwelling clandestinely among us pops up on religion and literature over and over again.
The oldest proven age for a humn so far is 122 (I think). That's well over twice the average lifespan in most nations today. Why not add another 60 years or so onto that? Assuming one could retain vigour and astuteness for most of it - I wouldn't want to senile and bedridden for 90 years or more!
We have a limited lifespan for a reason, or a variety of reasons. Mankind has improved on its natural condition ever since we started wearing clothes and making tools. Why shouldn't it be another logical step to overcome our genetic limitations and improve our bodies' durability? Certain anatomical modifications might be needed for a healthy second century, however - like a lower center of gravity, a thickened spine, knees which could bend both ways, a third and fourth dentition, regenerative eyes and nerves.
As for the obvious overpopulation potential associated with lengthening our lifespan: the nations with the highest standards of living are those with the lowest population growth today. People who live vastly longer will need fewer children; commensurate advances in agriculture, recycling and manufacturing techniques should make civilisation as whole more ecologically sustainable.
The population of First World countries may even SHRINK in the next 50 years as birthrate drops, and eventually the majority could be over 50. What of it? If medicine does enable people to stay healthy and capable for another 100 years, 50 or 90 will seem barely mature.