I do not see this 'direction' significance. How does it matter?
It matters a great deal.
In all variations of the double slit experiment, including the entangled version, choosing a slit is equivalent to choosing a direction. You either look at one slit, or the other. They aren't separated by a wide angle, but an angle separates them, and that is enough.
Choosing to observe one photon of an entangled pair, or one electron of an entangled pair makes a difference too, and for the same reason.
Choosing to view "bound or unbound" energy as a particle or a wave, equivalent to the uncertainty principle, makes a difference in terms of what one means by "locality", or position. Unbound energy only persists in time by propagating at c (being non-local). Bound energy only persists in time by being local. Together these two principles are simply the law of the conservation of energy, (energy persisting with respect to time) the most important principle in all of physics.
No matter how you observe energy, as a particle or as a wave, it is conserved. Of course, it will change the precision with which you can observe one (position or velocity, particle or wave) simply by observing the other kind of behavior. The difference in locality with respect to time is the reason. Unbound (wave) energy has inertia in only one direction. Bound energy has inertia in all directions at once, but can also be viewed as a wave.
Choosing to view a pair of simultaneous events separated by light travel time from a rest frame, or from opposing relativistic frames of reference along the line connecting those events will yield three different observations as to which event happened first, last, or at the same time. It is chiefly relativity that explains what an "observation" is, and why. Choosing a direction from which to observe is literally all there is to understand.
No other feature of an observer is important in any respect, least of all possessing cognition, which is possible with or without neurons anyway. Paramecia do it throughout their entire short life spans. No neurons. No brain cells or brain.
Finally, you are all viewing some really original stuff I am posting. This is a good deal deeper and much thicker than the stuff I posted when I first started here. I don't expect you to get it all at once, but thanks in advance for reading a little of it.