What do we know about how memory works?
Currently, two distinct flavours are modelled: short-term, or "working" memory, and long-term "stored" memory.
Plasticity is thought to be fundamental to the latter (it explains how we can recall vivid memories easily - it's modelled as actual neuronal structure and persistent connections between neurons). Short-term memory is modelled as a transient (but stable) activity pattern.
Here's an abstract from Science about some neural research:
Working memory is a modulation of neural activity.
Currently, two distinct flavours are modelled: short-term, or "working" memory, and long-term "stored" memory.
Plasticity is thought to be fundamental to the latter (it explains how we can recall vivid memories easily - it's modelled as actual neuronal structure and persistent connections between neurons). Short-term memory is modelled as a transient (but stable) activity pattern.
Here's an abstract from Science about some neural research:
Science 14 March 2008:
Vol. 319. no. 5869, pp. 1543 - 1546
DOI: 10.1126/science.1150769
Synaptic Theory of Working Memory
Gianluigi Mongillo1 Omri Barak2 Misha Tsodyks2
It is usually assumed that enhanced spiking activity in the form of persistent reverberation for several seconds is the neural correlate of working memory.
Here, we propose that working memory is sustained by calcium-mediated synaptic facilitation in the recurrent connections of neocortical networks.
In this account, the presynaptic residual calcium is used as a buffer that is loaded, refreshed, and read out by spiking activity.
Because of the long time constants of calcium kinetics, the refresh rate can be low, resulting in a mechanism that is metabolically efficient and robust.
The duration and stability of working memory can be regulated by modulating the spontaneous activity in the network.
1 Group for Neural Theory, Département d'Etudes Cognitives, Ecole Normale Supérieure et Collège-de-France, Paris, France.
2 Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Working memory is a modulation of neural activity.