Over 15 million people suffer from some form of blindness, with the most common conditions being retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Both of these conditions are caused when the photoreceptors in the eye are damaged. The photoreceptors are responsible for transforming light entering the eye into electrical impulses, but when damaged, the brain is unable to receive this information.
Horsager’s team is working with gene therapy and the gene responsible for making Channelrhodopsin-2 (ChR2) in algae. This photosensitive protein in the algae is what helps direct them toward a source of light.
The retina of the human eye is made up of three cellular layers. The first layer is the photoreceptors, which is what is damaged in people with RP and AMD. The second layer of the retina is made of bipolar cells which work to transmit information between the photoreceptors and the third layer, the ganglion. The ganglion is what then transmits light signals to the brain.
Horsager’s plan is to use the bipolar cells and make them work as photoreceptors as well. By injecting the algae gene into the bipolar cells, the idea is to have them produce the ChR2 and operate as a photoreceptor. With the bipolar cells able to sense light, they would then be able to transmit this information to the ganglion, which would then in turn transmit it to the brain.
Horsager’s team is working with gene therapy and the gene responsible for making Channelrhodopsin-2 (ChR2) in algae. This photosensitive protein in the algae is what helps direct them toward a source of light.
The retina of the human eye is made up of three cellular layers. The first layer is the photoreceptors, which is what is damaged in people with RP and AMD. The second layer of the retina is made of bipolar cells which work to transmit information between the photoreceptors and the third layer, the ganglion. The ganglion is what then transmits light signals to the brain.
Horsager’s plan is to use the bipolar cells and make them work as photoreceptors as well. By injecting the algae gene into the bipolar cells, the idea is to have them produce the ChR2 and operate as a photoreceptor. With the bipolar cells able to sense light, they would then be able to transmit this information to the ganglion, which would then in turn transmit it to the brain.
