..Most recently, evidence from
animal studies points to AGE restriction as an effective means for
extending median life span, similar to that previously shown by marked
caloric restriction. We conclude that excessive AGE consumption, in the
current dietary/social structure, represents an independent factor for
inappropriate oxidant stress responses, which may promote the premature
expression of complex diseases associated with adult life, such as
diabetes and cardiovascular disease.
http://www.annalsnyas.org/cgi/content/abstract/1043/1/452 "
"..Exogenous glycations and Advanced Glycation Endproducts (AGEs) are
typically formed when sugars are cooked with proteins or fats.
Temperatures over 120°C (~248°F) greatly accelerate the reactions,
but lower temperatures with longer cooking times also promote their
formation.
These compounds are absorbed by the body during digestion with about
30% efficiency....
..Endogenous glycations occur mainly in the bloodstream to a small
proportion of the absorbed simple sugars: glucose, fructose and
galactoseThis range of diseases is the result of the very basic level
at which glycations interfere with molecular and cellular functioning
throughout the body and the release of highly-oxidizing side products
such as hydrogen peroxide.
Glycated substances are eliminated from the body slowly, since the
renal clearance factor is only about 30%.
http://en.wikipedia.org/wiki/Glycation
