Two top immunologists agree with recent Nature paper, linked to in this article, finding that the monoclonal antibody cocktail ZMapp is the most effective anti-Ebola drug yet. US HSS has set aside $24 million to accelerate production, it announced last week. But two vaccines, one developed by the NIH, are also on the way. See the article "ZMapp: Best Anti-Ebola Drug Yet" in Drug Discovery & Development online.
Curing 18 of 18 monkeys, ZMapp "most effective" anti-Ebola drug yet, sez Nature study
- Thread starter binnie
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ps; welcome to sciforums, thanks for referencing this, you just might have saved someone's life.
One of the sad consequences of this is that gravely ill patients have to be used as test subjects. Too bad the vaccine could not have been developed before the outbreak.
We need something to incentivize cure research before it can begin --- the loss of human lives because of this disease is a sad, but necessary to fund cure research. If you will remember (or if you are old enough to remember) HIV/AIDS had absolutely no funding until it became pandemic.
Well, given that it might have some pretty grievous side effects, you probably don't want it widely distributed yet. Let's say it only kills .01% of the people it is used on - it would still be far worse than the disease.
However I agree that it's looking very promising, and I'm glad it is getting the attention it is.
According to this article, the Zmapp method of producing MAbs is going to be very expensive because the combined amount required is very high,
12 grams or so, necessitating extracting the antibodies from 360 Kg of Nicotiana benthamiana, per patient.
It also suggests that older methods of producing MAbs may be more cost effective.
https://rybicki.wordpress.com/2014/10/08/norway-to-get-worlds-last-dose-of-zmapp/
I can't find any projected costing for a course of Zmapp, 3 injections of 4 grams.
$100,000? Just a guess.
In Africa, the best way of boosting antibodies may turn out to be blood transfusions from cured patients.
12 grams or so, necessitating extracting the antibodies from 360 Kg of Nicotiana benthamiana, per patient.
It also suggests that older methods of producing MAbs may be more cost effective.
https://rybicki.wordpress.com/2014/10/08/norway-to-get-worlds-last-dose-of-zmapp/
I can't find any projected costing for a course of Zmapp, 3 injections of 4 grams.
$100,000? Just a guess.
In Africa, the best way of boosting antibodies may turn out to be blood transfusions from cured patients.
Correction.
Not blood, Plasma.
http://www.dddmag.com/news/2014/10/how-plasma-transfusions-survivors-fight-ebola
Not blood, Plasma.
http://www.dddmag.com/news/2014/10/how-plasma-transfusions-survivors-fight-ebola