Aluminum and Alzheimers?

[Hurricane Angel]

Is there any definitive correlation? I have hyperhydrosis of the palms and my doctor suggested i use metallic salts, more specificly aluminum chloride. Now if there was any correlation of alzheimers and aluminum, how much would be getting into my body by using the solution on my palms?

Any ideas?

 

[Trilobyte]

What made you relate aluminium and alzheimers in the first place?

 

[cato]

aluminum chloride, I think most underarm antiperspirants use that. let me go check.... well, I think some do, but the only one I could find had a different aluminum molecule.

 

[Hurricane Angel]

What made you relate aluminium and alzheimers in the first place?

I've heard about it many times, but never anything solidly factual.

 

[tablariddim]

You can always go and have some chelation therapy after a while and that will get rid of the aluminium in your arteries.

 

[CharonZ]

Cell Mol Life Sci. 2005 Jan;62(2):143-58. Related Articles, Links

Aluminium in Alzheimer's disease: are we still at a crossroad?

Gupta VB, Anitha S, Hegde ML, Zecca L, Garruto RM, Ravid R, Shankar SK, Stein R, Shanmugavelu P, Jagannatha Rao KS.

Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, 570020, India. kjr4n@yahoo.com

Aluminium, an environmentally abundant non-redox trivalent cation has long been implicated in the pathogenesis of Alzheimer's disease (AD). However, the definite mechanism of aluminium toxicity in AD is not known. Evidence suggests that trace metal homeostasis plays a crucial role in the normal functioning of the brain, and any disturbance in it can exacerbate events associated with AD. The present paper reviews the scientific literature linking aluminium with AD. The focus is on aluminium levels in brain, region-specific and subcellular distribution, its relation to neurofibrillary tangles, amyloid beta, and other metals. A detailed mechanism of the role of aluminium in oxidative stress and cell death is highlighted. The importance of complex speciation chemistry of aluminium in relation to biology has been emphasized. The debatable role of aluminium in AD and the cross-talk between aluminium and genetic susceptibility are also discussed. Finally, it is concluded based on extensive literature that the neurotoxic effects of aluminium are beyond any doubt, and aluminium as a factor in AD cannot be discarded. However, whether aluminium is a sole factor in AD and whether it is a factor in all AD cases still needs to be understood.